Providing better-matched donors for HLA mismatched compatible pairs through kidney paired donation

Ferrari, P., Cantwell, L., Ta, J., Woodroffe, C., DʼOrsogna, L. and Holdsworth, R. (2017) Providing better-matched donors for HLA mismatched compatible pairs through kidney paired donation. Transplantation, 101 (3). pp. 642-648.

Abstract

BACKGROUND:
Participation of compatible pairs (CP) in kidney paired donation (KPD) could be attractive to CPs who have a high degree of HLA mismatch, if the CP recipient will gain a better HLA match. Because KPD programs were not designed to help CP, it is important to define allocation metrics that enable CP to receive a better-matched kidney, without disadvantage to incompatible pairs (ICP).

METHODS:
Simulations using 46 ICPs and 11 fully HLA-mismatched CPs were undertaken using the Australian KPD matching algorithm. Allocations were preformed adding 1 CP at a time or all 11 CPs at once, and with and without exclusion of unacceptable antigens selected to give a virtual calculated panel-reactive antibody ranging 70% to 80% to improve HLA matching in CP recipients.

RESULTS:
On average, most CP recipients could be matched and had a lower eplet mismatch (EpMM) with the matched donor (57 ± 15) than with their own donor (78 ± 19, P < 0.02). However, only recipients who had an EpMM to own donor greater than 65 achieved a significant reduction in the EpMM with the matched donor. The gain in EpMM was larger when CPs were listed with unacceptable antigens. Furthermore, inclusion of 1 CP at a time increased matching in ICP by up to 33%, and inclusion of all 11 CPs at once increased ICP matching by 50%.

CONCLUSIONS:
Compatible pair participation in KPD can increase match rates in ICP and can provide a better immunological profile in CP recipients who have a high EpMM to their own donor when using allocation based on virtual crossmatch.

Item Type:	Journal Article
Publisher:	Lippincott, Williams & Wilkins
Copyright:	© 2016 Wolters Kluwer Health, Inc
URI:	http://researchrepository.murdoch.edu.au/id/eprint/38743

Item Control Page