Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle

Ditcham, W.G.F., Lewis, J.R., Dobson, R.J., Hartaningsih, N., Wilcox, G.E. and Desport, M. (2009) Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle. Virology, 386 (2). pp. 317-324.

PDF - Authors' Version
Download (464kB)
Free to read:
*No subscription required


The efficacy of a tissue-derived vaccine, which is currently used in Indonesia to control the spread of Jembrana disease in Bali cattle, was determined by quantifying the viral load in plasma following experimental infection with Jembrana disease virus. Virus transmission is most likely to occur during the acute phase of infection when viral titers are greater than 106 genomes/ml. Vaccinated cattle were found to have a 96% reduction in viral load above this threshold compared to control cattle. This would reduce the chance of virus transmission as the number of days above the threshold in the vaccinated cattle was reduced by 33%. Viral loads at the onset and resolution of fever were significantly lower in the vaccinated cattle and immune function was maintained with the development of antibody responses to Env proteins within 10-24 days post challenge. There was, however, no significant reduction in the duration of the febrile period in vaccinated animals. The duration and severity of clinical parameters were found to be variable within each group of cattle but the quantification of viral load revealed the benefits of vaccinating to reduce the risk of virus transmission as well as to ameliorate disease.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Academic Press
Item Control Page Item Control Page


Downloads per month over past year