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The 3 Cs of antibiotic allergy—classification, cross-reactivity, and collaboration

Trubiano, J.A., Stone, C.A., Grayson, M.L., Urbancic, K., Slavin, M.A., Thursky, K.A. and Phillips, E.J. (2017) The 3 Cs of antibiotic allergy—classification, cross-reactivity, and collaboration. The Journal of Allergy and Clinical Immunology: In Practice, 5 (6). pp. 1532-1542.

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Antibiotic allergy labeling is highly prevalent and negatively impacts patient outcomes and antibiotic appropriateness. Reducing the prevalence and burden of antibiotic allergies requires the engagement of key stakeholders such as allergists, immunologists, pharmacists, and infectious diseases physicians. To help address this burden of antibiotic allergy overlabeling, we review 3 key antibiotic allergy domains: (1) antibiotic allergy classification, (2) antibiotic cross-reactivity, and (3) multidisciplinary collaboration. We review the available evidence and research gaps of currently used adverse drug reaction classification systems, antibiotic allergy cross-reactivity, and current and future models of antibiotic allergy care.

Item Type: Journal Article
Murdoch Affiliation(s): Institute for Immunology and Infectious Diseases
Publisher: Elsevier
Copyright: © 2017 American Academy of Allergy, Asthma & Immunology
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