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Next-Generation Nucleic Acid Aptamers with Two-Base-Modified Nucleotides Have Improved Binding Affinity and Potency

Al Shamaileh, H. and Veedu, R.N. (2017) Next-Generation Nucleic Acid Aptamers with Two-Base-Modified Nucleotides Have Improved Binding Affinity and Potency. ChemBioChem, 18 (16). pp. 1565-1567.

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Link to Published Version: https://doi.org/10.1002/cbic.201700276
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Abstract

Twice as apt: Nucleic acid aptamers with high binding affinity, specificity, epitope coverage and nuclease resistance were developed by using libraries containing oligonucleotides in which two bases in the pyrimidine nucleotide had been modified.

Item Type: Journal Article
Murdoch Affiliation: Centre for Comparative Genomics
Publisher: Wiley
Copyright: © 2017 John Wiley & Sons, Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/37590
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