Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Next-Generation Nucleic Acid Aptamers with Two-Base-Modified Nucleotides Have Improved Binding Affinity and Potency

Tools

Al Shamaileh, H. and Veedu, R.N. (2017) Next-Generation Nucleic Acid Aptamers with Two-Base-Modified Nucleotides Have Improved Binding Affinity and Potency. ChemBioChem, 18 (16). pp. 1565-1567.

[img]
Preview
PDF - Authors' Version
Download (1MB) | Preview
Link to Published Version: https://doi.org/10.1002/cbic.201700276
*Subscription may be required

Abstract

Twice as apt: Nucleic acid aptamers with high binding affinity, specificity, epitope coverage and nuclease resistance were developed by using libraries containing oligonucleotides in which two bases in the pyrimidine nucleotide had been modified.

Item Type: Journal Article
Murdoch Affiliation: Centre for Comparative Genomics
Publisher: Wiley
Copyright: © 2017 John Wiley & Sons, Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/37590
Item Control Page Item Control Page

Downloads

Downloads per month over past year