Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells

Lucas, M., Day, C. L., Wyer, J. R., Cunliffe, S. L., Loughry, A., McMichael, A. J. and Klenerman, P. (2004) Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells. Journal of Virology, 78 (13). pp. 7284-7287.

Abstract

Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct “central memory” CD62L+ phenotype.

Item Type:	Journal Article
Murdoch Affiliation(s):	Institute for Immunology and Infectious Diseases
Publisher:	American Society for Microbiology
Copyright:	@ American Society for Microbiology
URI:	http://researchrepository.murdoch.edu.au/id/eprint/37289

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