Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
Lucas, M., Day, C. L., Wyer, J. R., Cunliffe, S. L., Loughry, A., McMichael, A. J. and Klenerman, P. (2004) Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells. Journal of Virology, 78 (13). pp. 7284-7287.
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Abstract
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct “central memory” CD62L+ phenotype.
Item Type: | Journal Article |
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Murdoch Affiliation(s): | Institute for Immunology and Infectious Diseases |
Publisher: | American Society for Microbiology |
Copyright: | @ American Society for Microbiology |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/37289 |
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