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New biosensors made of specially designed transparent chips with nano-optical tags

Liu, S., Xu, Z-P, Yu, A., Su, H. and Liu, L. (2007) New biosensors made of specially designed transparent chips with nano-optical tags. Smart Materials and Structures, 16 (6). pp. 2214-2221.

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Transparent chips with regular micrometer posts were fabricated from glass slides, glass wafers and silicon wafers via the available photolithography and pattern transfer techniques. The fabrication conditions, e.g. the substrate type, the photomask type, the etchant composition and the etching time, have been adjusted to pattern chips with post height of 6–70 µm. On the other hand, colloidal Au particles with size of 12 nm were synthesized by the reduction of tetrachloroauric acid and further modified by mercaptoundecanoic acid into nano-optical tags. The functionalization of transparent chips with 3-aminopropyltrimethoxysilane brings about the attachment of modified Au nanoparticles onto the surface, which shows characteristic UV–vis absorbance and indicates the feasibility as a new type of biosensor based on a specially patterned chip with high sensitivity.

Item Type: Journal Article
Publisher: Institute of Physics Publishing
Copyright: (c) Institute of Physics Publishing
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