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Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection

Lim, A., Amini, A., D’Orsogna, L.J., Rajasuriar, R., Kramski, M., Lewin, S.R., Purcell, D.F., Price, P. and French, M.A. (2011) Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection. AIDS, 25 (11). pp. 1379-1383.

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Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection.
Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n = 23) and ART-treated (n = 27) HIV patients.
Methods: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma.
Results: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P = 0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P < 0.0001) and levels of IgG anti-LPS correlated with IgM+ memory B-cell counts (P = 0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4+ T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA.
Conclusion: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients.

Item Type: Journal Article
Publisher: Lippincott Williams & Wilkins Ltd.
Copyright: © 2017 Wolters Kluwer Health, Inc.
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