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Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Armstrong, N.J.ORCID: 0000-0002-4477-293X, Mather, K.A., Thalamuthu, A., Wright, M.J., Trollor, J.N., Ames, D., Brodaty, H., Schofield, P.R., Sachdev, P.S. and Kwok, J.B. (2017) Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks. Epigenomics, 9 (5). pp. 689-700.

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Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

Item Type: Journal Article
Murdoch Affiliation(s): School of Mathematical and Physical Sciences
Publisher: Future Medicine Ltd
Copyright: © 2017 Future Medicine Ltd
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