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Contribution of Diet and Exercise in the Pathogenesis of Major Depression

Lopresti, A.L.ORCID: 0000-0002-6409-7839 (2015) Contribution of Diet and Exercise in the Pathogenesis of Major Depression. In: Farooqui, T. and Farooqui, A.A., (eds.) Diet and Exercise in Cognitive Function and Neurological Diseases. Wiley Blackwell, Hoboken, New Jersey, pp. 93-104.

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Major depression is a debilitating condition affecting approximately 10% of the population. While primary treatments comprise pharmaceutical and/or psychological interventions, efficacy rates are far from ideal, reaching treatment remission rates of only 20-40%. Diet and exercise are two lifestyle factors that are commonly associated with major depression and have the potential to increase treatment efficacy. In this chapter, epidemiological and interventional studies on diet and exercise in major depression will be reviewed with a particular emphasis on their role in the prevention and treatment of this disorder. The influence of diet and exercise on dysregulated biological pathways associated with depression will also be summarized, namely, their impact on neurotransmitter balance, oxidative stress, inflammation, neurogenesis, and hypothalamus-adrenal-pituitary (HPA) axis regulation.

Item Type: Book Chapter
Murdoch Affiliation(s): School of Psychology and Exercise Science
Publisher: Wiley Blackwell
Copyright: 2015
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