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Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia

van Hal, S.J., Espedido, B.A., Coombs, G.W.ORCID: 0000-0003-1635-6506, Howden, B.P., Korman, T.M., Nimmo, G.R., Gosbell, I.B. and Jensen, S.O. (2017) Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia. Journal of Antimicrobial Chemotherapy, 72 (4). pp. 998-1001.

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Link to Published Version: http://dx.doi.org/10.1093/jac/dkw539
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Abstract

Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
Copyright: © The Author 2016
United Nations SDGs: Goal 3: Good Health and Well-Being
URI: http://researchrepository.murdoch.edu.au/id/eprint/36730
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