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The Synthesis of 4,6,8-Trimethoxy-1-naphthol. A New Approach

Giles, R.G.F., Green, I.R. and Hugo, V.I. (1989) The Synthesis of 4,6,8-Trimethoxy-1-naphthol. A New Approach. South African Journal of Chemistry, 42 (4). pp. 162-163.

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4,6,8-Trimethoxy-1-naphthol (1)1 is an important intermediate in the synthesis of a large number of naturally occurring oxygenated naphtho[2,3-c] pyranquinones. A key step in the formation of this material involves enolization and methylation of the enol ether (7) formed by a Diels-Alder reaction, followed by pyrolysis of the product (8).

Item Type: Journal Article
Publisher: South African Bureau for Scientific Publications
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