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Synthesis of (1S)-N-(1-carboxy-5-aminopentyl)-glycylglycine - a prospective competitive inhibitor for angiotensin-converting enzyme

Yorke, S.C., Ehlers, M.R.W., Kirsch, R.E. and Giles, R.G.F. (1986) Synthesis of (1S)-N-(1-carboxy-5-aminopentyl)-glycylglycine - a prospective competitive inhibitor for angiotensin-converting enzyme. South African Journal of Chemistry, 39 (3). pp. 134-136.

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Abstract

The synthesis of a prospective competitive inhibitor of angiotensin-converting enzyme, (1 S )-N-(1-carboxy-5- aminopentyllglycylglycine (4), was accomplished in four steps in 72% overall yield starting from glycine. Hydrogenolysis of the benzyl and benzyloxycarbonyl protective groups in the last step was enhanced by the use of ultrasound.

Item Type: Journal Article
Publisher: South African Bureau for Scientific Publications
Copyright: © 1986 South African Chemical Institute (SACI)
URI: http://researchrepository.murdoch.edu.au/id/eprint/35680
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