Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Extended spectrum cephalosporins and Clostridium difficile

Golledge, C.L., McKenzie, T. and Riley, T.V. (1989) Extended spectrum cephalosporins and Clostridium difficile. Journal of Antimicrobial Chemotherapy, 23 (6). pp. 929-931.

Link to Published Version:
*Subscription may be required


There is little information about how commonly the newer cephalosporins cause diarrhoea due to Clostridium difficile. In this study of 111 patients with C. difficile-associated diarrhoea, 106 had received antimicrobial agents in the four weeks before detection of C. difficile. The relative risk for each antimicrobial agent was greatest with clindamycin, followed by cefotaxime, cephamandole and ceftriaxone. There was no statistically significant difference in risk between the cephalosporins evaluated. Narrower spectrum penicillins, anti-pseudomonal penicillins and aminoglycosides were not potent inciting agents.

Item Type: Journal Article
Publisher: Oxford University Press
Copyright: © 1989 The British Society for Antimicrobial Chemotherapy
Item Control Page Item Control Page