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Clostridium difficile-associated diarrhoea

Elliott, B., Chang, B.J., Golledge, C.L. and Riley, T.V. (2007) Clostridium difficile-associated diarrhoea. Internal Medicine Journal, 37 (8). pp. 561-568.

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Clostridium difficile is an important nosocomial pathogen and the most frequently diagnosed cause of infectious hospital-acquired diarrhoea. Toxigenic strains usually produce toxin A and toxin B, which are the primary virulence factors of C. difficile. Some recently described strains produce an additional toxin, an adenosine-diphosphate ribosyltransferase known as binary toxin, the role of which in pathogenicity is unknown. There has been concern about the emergence of a hypervirulent fluoroquinolone-resistant strain of C. difficile in North America and Europe. The use of fluoroquinolone antimicrobials appears to be acting as a selective pressure in the emergence of this strain. In this review, we describe the current state of knowledge about C. difficile as a cause of diarrhoeal illness.

Item Type: Journal Article
Publisher: Wiley
Copyright: © 2007 Royal Australasian College of Physicians
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