Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum
Boxell, A., Lee, S.H.C., Jefferies, R., Watt, P., Hopkins, R., Reid, S., Armson, A. and Ryan, U.ORCID: 0000-0003-2710-9324
(2008)
Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum.
Experimental Parasitology, 119
(2).
pp. 301-303.
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Abstract
This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
Item Type: | Journal Article |
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Murdoch Affiliation(s): | School of Veterinary and Biomedical Sciences School of Nursing & Midwifery |
Publisher: | Academic Press |
Copyright: | © 2008 Elsevier Inc. |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/3417 |
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