Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum

Boxell, A., Lee, S.H.C., Jefferies, R., Watt, P., Hopkins, R., Reid, S., Armson, A. and Ryan, U.ORCID: 0000-0003-2710-9324 (2008) Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum. Experimental Parasitology, 119 (2). pp. 301-303.

Abstract

This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.

Item Type:	Journal Article
Murdoch Affiliation(s):	School of Veterinary and Biomedical Sciences School of Nursing & Midwifery
Publisher:	Academic Press
Copyright:	© 2008 Elsevier Inc.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/3417

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