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Proton pump inhibitors and diarrhoea related to Clostridium difficile infection in hospitalised patients: a case-control study

Leonard, A.D., Ho, K.M. and Flexman, J. (2012) Proton pump inhibitors and diarrhoea related to Clostridium difficile infection in hospitalised patients: a case-control study. Internal Medicine Journal, 42 (5). pp. 591-594.

Link to Published Version: http://dx.doi.org/10.1111/j.1445-5994.2012.02770.x
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Abstract

The incidence and disease severity of Clostridium difficile infection are rising. There is increasing evidence of a potential association between proton-pump inhibitors (PPI) and C. difficile infection. We performed a case–control study to examine the relationship between PPI and polymerase chain reaction (PCR)-proven C. difficile infection in 137 hospitalised patients in a tertiary hospital in Western Australia. Only antibiotic exposure within 3 months prior to onset of diarrhoea was associated with PCR-proven C. difficile infection (odds ratio 5.97, 95% confidence interval 2.40–14.8, P= 0.001). A restricted analysis on those who had exposure to antibiotics within 3 months before the onset of diarrhoea did not change the negative association between PPI exposure and PCR-proven C. difficile infection. Long-term PPI usage and intensity of PPI exposure prior to onset of diarrhoea were not significantly associated with C. difficile infection.

Item Type: Journal Article
Publisher: Wiley
Copyright: © 2012 Royal Australasian College of Physicians
URI: http://researchrepository.murdoch.edu.au/id/eprint/34094
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