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Transferable tetracycline resistance in Clostridium perfringens strains of porcine origin

Rood, J.I. (1983) Transferable tetracycline resistance in Clostridium perfringens strains of porcine origin. Canadian Journal of Microbiology, 29 (10). pp. 1241-1246.

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These studies represent the first systematic survey of the incidence of conjugative antibiotic resistance in Clostridium perfringens. Ninety-two antibiotic-resistant porcine strains were examined to see if they could donate their antibiotic-resistance determinants to sensitive recipient strains. Fifteen of the 89 tetracycline-resistant strains transferred their tetracycline resistance in mixed-plate mating experiments but no transfer of macrolide-lincosamide resistance was detected. The efficiencies of transfer of tetracycline resistance varied from 1.3 X 10(-3) to 1.9 X 10(-6) transconjugants per donor cell. Significantly higher transfer efficiencies were observed when both the donor and recipient strains were derivatives of strain CW 362. These values ranged from 3.7 X 10(-1) to 4.6 X 10(-2) transconjugants per donor cell. This high frequency transfer system should prove invaluable for further genetic studies on this microorganism.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary Studies
Publisher: National Research Council Canada
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