Swainsonine affects the processing of glycoproteins in vivo
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Abraham, D.J., Sidebothom, R., Winchester, B.G., Dorling, P.R. and Dell, A. (2001) Swainsonine affects the processing of glycoproteins in vivo. FEBS Letters, 163 (1). pp. 110-113.
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Abstract
Rats, sheep and guinea pigs treated with swainsonine excrete 'high mannose' oligosaccharides in urine. The major rat and guinea pig oligosaccharide is (Man)5GlcNAc whereas sheep excrete a mixture of oligosaccharides of composition (Man)2-5GlcNAc2 and (Man)3-5GlcNAc. The presence of these oligosaccharides suggests that Golgi α-D-mannosidase II as well as lysosomal α-D-mannosidase is inhibited by swainsonine resulting in storage of abnormally processed asparagine-linked glycans from glycoproteins. Altered glycoprotein processing appears to have little effect on the health of the intoxicated animal, but the accompanying lysosomal storage produces a disease state.
| Item Type: | Journal Article |
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| Murdoch Affiliation(s): | School of Veterinary Studies |
| Publisher: | Elsevier |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/33764 |
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