Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Identification of genes involved with tick infestation in Bos taurus and Bos indicus

Kongsuwan, K., Piper, E.K., Bagnall, N.H., Ryan, K., Moolhuijzen, P., Bellgard, M., Lew, A., Jackson, L. and Jonsson, N.N. (2008) Identification of genes involved with tick infestation in Bos taurus and Bos indicus. Developments in Biologicals, 132 . pp. 77-88.

Link to Published Version:
*Subscription may be required


Tick resistant cattle could provide a potentially sustainable and environmentally sound method of controlling cattle ticks. Advances in genomics and the availability of the bovine genome sequence open up opportunities to identify useful and selectable genes controlling cattle tick resistance. Using quantitative real-time PCR and the Affymetrix bovine array platform, differences in gene expression of skin biopsies from tick resistant Bos indicus (Brahman) and tick susceptible Bos taurus (Holstein-Friesian) cattle following tick challenge were examined. We identified 138 significant differentially-expressed genes, including several immunological/host defence genes, extracellular matrix proteins, and transcription factors as well as genes involved in lipid metabolism. Three key pathways, represented by genes differentially expressed in resistant Brahmans, were identified; the development of the cell-mediated immune response, structural integrity of the dermis and intracellular Ca 2+ levels. Ca2+, which is implicated in host responses to microbial stimuli, may be required for the enhancement or fine-tuning of transcriptional activation of Ca2+- dependant host defence signalling pathways.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Comparative Genomics
Publisher: S. Karger AG
Copyright: © 2010 S. Karger AG, Basel
Notes: Paper presented at the International Symposium on Animal Genomics for Animal Health, Paris, 23-25 October 2007
Item Control Page Item Control Page