Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Strain- and age-associated variation in viral persistence and antibody response to mouse parvovirus 1 in experimentally infected mice

Filipovska-Naumovska, E., Thompson, M.J., Hopwood, D., Pass, D.A. and Wilcox, G.E. (2010) Strain- and age-associated variation in viral persistence and antibody response to mouse parvovirus 1 in experimentally infected mice. Journal of the American Association for Laboratory Animal Science, 49 (4). pp. 443-447.

Free to read: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC291918...
*No subscription required

Abstract

The effect of mouse strain and age at infection on viral replication and concurrent antibody response to mouse parvovirus 1 (isolate MPV1f) was evaluated for 305 d after inoculation in 4 strains of mice. The results confirmed previous reports that mouse strain and age at infection are significant factors in viral persistence and antibody development and detection. Randombred Arc:Arc(s) mice originally bred from CD1 stock inoculated as juveniles (4 wk) or adults (8 wk) developed persistent viral infection for 152 d after inoculation and an antibody response that persisted for 295 d. Mice of C57BL/6J background inoculated as juveniles had detectable viral DNA in large intestinal content and tissues for 24 d after inoculation and an antibody response that persisted for 288 d. However, viral DNA was not detected in tissues of C57BL/6J mice inoculated as adults, although an antibody was detected for 111 d after inoculation; these results suggest probable viral replication in adult C57BL/6J mice but at levels below the limits of detection. BALB/cArc mice inoculated as juveniles or adults had detectable virus DNA in tissues for 108 to 242 d after inoculation, but no antibody was detected. Similarly, BALB/c-Foxn1 nu/ArC mice had detectable levels of viral DNA in tissues for 98 to 131 d but no measurable antibody. The difficulty of detecting antibody in mice with a BALB/c background indicates they are unsuitable for routine surveillance of MPV1f infection.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Biomedical Sciences
Publisher: American Association for Laboratory Animal Science
Copyright: 2010 by the American Association for Laboratory Animal Science
URI: http://researchrepository.murdoch.edu.au/id/eprint/3312
Item Control Page Item Control Page