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The role of IL-22 in viral infections: Paradigms and paradoxes

Gimeno Brias, S., Stack, G., Stacey, M.A., Redwood, A.J. and Humphreys, I.R. (2016) The role of IL-22 in viral infections: Paradigms and paradoxes. Frontiers in Immunology, 7 .

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Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.

Item Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Journal or Publication Title: Frontiers in Immunology
Publisher: Frontiers Media
Copyright: 2016 Gimeno Brias et al.
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