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Hybridization based enrichment for genotyping HLA and KIR genes using Next Generation Sequencing

Cooper, D., Chopra, A., Blinco, J., Leary, S., Watson, M.ORCID: 0000-0002-6438-9225 and Mallal, S. (2015) Hybridization based enrichment for genotyping HLA and KIR genes using Next Generation Sequencing. In: Science on the Swan, 21 - 23 April 2015, Perth, Western Australia.

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Abstract

Several disease association studies indicate that, the interactions between the KIR and HLA loci may have a role in infectious diseases, autoimmune disorders, cancer and reproduction. Current typing methods for HLA Loci use PCR for whole gene amplification or selected exon amplification. The Killer cell immunoglobulin-like receptors (KIR) genes are polymorphic and the gene complex is polygenic with a varying number of inhibitory (iKIRs) and activating (aKIRs) receptors. Due to this complexity of the KIR locus, genotyping is not performed as routinely.

Item Type: Conference Item
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Conference Website: http://www.scienceontheswan.com.au/
URI: http://researchrepository.murdoch.edu.au/id/eprint/31889
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