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Cutting edge tools for phenotyping and characterising T-Cell subsets

Chopra, A., Gaudieri, S., Pilkington, M., Blinco, J., Leary, S., Cooper, D., Abana, C., Watson, M.ORCID: 0000-0002-6438-9225, Kalams, S. and Mallal, S. (2016) Cutting edge tools for phenotyping and characterising T-Cell subsets. In: Science on the Swan 2016, 2 - 5 May 2016, Perth, Western Australia.

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Next generation Sequencing (NGS) has enabled high throughput analysis of T cell receptor (TCR) repertoires, which are useful for monitoring antigen- specific T cell responses. Integrating TCR sequencing with expression levels of genes that characterise T cell phenotype at the single cell level allows comprehensive analysis of T cell function and specificity. Single cell TCR sequencing on the Illumina platform enables the identification of paired TCR α/β chains and T cell phenotype from sorted antigen-specific T cell populations. Here we highlight novel techniques available for T cell phenotyping and TCR repertoire analysis.

Item Type: Conference Item
Murdoch Affiliation(s): Institute for Immunology and Infectious Diseases
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