Comparative study of the antioxidant defence systems in the erythrocytes of australian marsupials and monotremes
Whittington, A.T., Parkinson, A.L., Spencer, P.B.S.ORCID: 0000-0002-4938-2615, Grigg, G., Hinds, L., Gallagher, C.H., Kuchel, P.W. and Agar, N.S.
(1995)
Comparative study of the antioxidant defence systems in the erythrocytes of australian marsupials and monotremes.
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 110
(3).
pp. 267-272.
*Subscription may be required
Abstract
A comparison of the erythrocyte (RBC) antioxidant metabolites and enzymes in nine marsupial and two monotreme species was carried out. Reduced glutathione (GSH) concentrations were comparable with those reported for other marsupial and eutherian species. An important finding was that the erythrocytes of the southern hairy nosed wombat regenerated GSH faster than the erythrocytes from its close relative, the common wombat. The activities of glutathione-S-transferase, NADH-methaemoglobin reductase, Superoxide dismutase, and glutathione peroxidase (GSH-Px), showed similar levels and extents of variation as those observed in other marsupial and eutherian species. Catalase activities in the marsupials were lower than those measured in the two monotreme species and much lower than those reported in eutherian species. A negative correlation, significant at P < 0.05, was observed between GSH-Px and catalase activities in the RBC of the marsupials. Since both these enzymes "detoxify" H2O2, there appears to be a reciprocal relationship between the activities of these enzymes in marsupial RBC.
Item Type: | Journal Article |
---|---|
Publisher: | Elsevier B.V. |
Copyright: | © 1995 Published by Elsevier Inc |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/30464 |
![]() |
Item Control Page |
Downloads
Downloads per month over past year