A comparison of the palatability of racemic praziquantel and its two enantioseparated isomers in yellowtail kingfish Seriola lalandi (Valenciennes, 1833)
Partridge, G.J., Burge, T. and Lymbery, A.J.ORCID: 0000-0002-0542-3446
(2017)
A comparison of the palatability of racemic praziquantel and its two enantioseparated isomers in yellowtail kingfish Seriola lalandi (Valenciennes, 1833).
Aquaculture Research, 48
(4).
pp. 1735-1743.
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Abstract
The bitterness of racemic praziquantel (Rac-PZQ) constrains its use as an in-feed treatment against monogenean flukes in finfish aquaculture. Evidence exists in mammals that the R-(-) enantiomer of PZQ is less bitter than the S-(+) enantiomer. If fish exhibit this same response, then the recently described techniques for the large-scale resolution of R-(-)-PZQ from Rac-PZQ could facilitate the wide-spread application of this effective anthelmintic compound via feed. The hypothesis that yellowtail kingfish Seriola lalandi would find R-(-)-PZQ more palatable than Rac-PZQ and S-(+)-PZQ was tested in four trials. During the first three trials, the palatability of diets top-coated with 10 g kg-1 of Rac-PZQ or its two enantioseparated isomers were compared in small (85-160 g) and large (1.2 kg) yellowtail kingfish. A fourth trial compared the palatability of R-(-)-PZQ and Rac-PZQ at dietary inclusion levels of 2.5, 5.0 and 10.0 g kg-1 in small yellowtail kingfish (170 g). Ingestion data showed that R-(-)-PZQ to be no more palatable than either Rac-PZQ or S-(+)-PZQ to yellowtail kingfish, regardless of size. Indeed, evidence suggested that the S-(+)-PZQ to be slightly more palatable than both R-(-)-PZQ and Rac-PZQ. From these data, we hypothesize that the strong smell of R-(-)-PZQ (which was not present in S-(+)-PZQ) is an equally important determinant to palatability as taste in yellowtail kingfish. Results demonstrate that dietary inclusion level is a more important determinant to palatability than PZQ chirality; however, administration of R-(-)-PZQ may still be advantageous if it is demonstrated to be the only enantiomer efficacious against monogeneans.
Item Type: | Journal Article |
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Murdoch Affiliation(s): | School of Veterinary and Life Sciences Freshwater Fish Group & Fish Health Unit |
Publisher: | Blackwell Publishing Inc |
Copyright: | © 2016 John Wiley & Sons Ltd |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/30301 |
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