Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment

Fabis-Pedrini, M.J., Xu, W., Burton, J., Carroll, W.M. and Kermode, A.G. (2016) Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment. Journal of Clinical Neuroscience, 25 . pp. 145-147.

Link to Published Version: http://dx.doi.org/10.1016/j.jocn.2015.08.027
*Subscription may be required

Abstract

We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening in a 40-year-old patient with subsequent benign course with 12 months follow-up. The patient had a history of aggressive inflammatory multiple sclerosis, prior mitoxantrone therapy, Stratify John Cunningham Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and 5 years of natalizumab monotherapy. The initial MRI detection of PML was both atypical and subtle. Early diagnosis and intervention, and pre-emptive treatment for immune reconstitution inflammatory syndrome with high dose steroids, as well as empirical mirtazapine and mefloquine, were associated with a benign PML disease course and outcome.

Item Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Churchill Livingstone
Copyright: © 2015 Elsevier Ltd.
URI: http://researchrepository.murdoch.edu.au/id/eprint/29997
Item Control Page Item Control Page