Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Biochemical changes within a multiple sclerosis plaque in vivo

Cadoux-Hudson, T.A., Kermode, A., Rajagopalan, B., Taylor, D., Thompson, A.J., Ormerod, I.E., McDonald, W.I. and Radda, G.K. (1991) Biochemical changes within a multiple sclerosis plaque in vivo. Journal of Neurology, Neurosurgery & Psychiatry, 54 (11). pp. 1004-1006.

Link to Published Version: http://dx.doi.org/10.1136/jnnp.54.11.1004
*Subscription may be required
Free to read: https://www.ncbi.nlm.nih.gov/pubmed/1666122
*No subscription required

Abstract

Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing a large multiple sclerosis (MS) lesion. Reduced levels of phosphocreatine (PCr) relative to adenosine triphosphate (ATP) were found suggesting an abnormality in energy metabolism, with an increase in the phosphodiester (PDE) peak. A follow up study 16 months later revealed reduction in size of the lesion on MRI and normal intracellular biochemistry by MRS. Four MS patients without visible superficial cerebral lesions showed no significant changes in phosphorus metabolism.

Item Type: Journal Article
Publisher: BMJ Publishing Group
URI: http://researchrepository.murdoch.edu.au/id/eprint/29303
Item Control Page Item Control Page