Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Magnetic resonance imaging in Leber's optic neuropathy

Kermode, A.G., Moseley, I.F., Kendall, B.E., Miller, D.H., Macmanus, D.G. and McDonald, W.I. (1989) Magnetic resonance imaging in Leber's optic neuropathy. Journal of Neurology, Neurosurgery & Psychiatry, 52 (5). pp. 671-674.

Link to Published Version:
*Subscription may be required


Thirteen males with Leber's optic neuropathy had magnetic resonance imaging (MRI) of the brain, and in eight the optic nerves were imaged using STIR (Short Time Inversion Recovery) sequences. All optic nerve scans were abnormal. In seven with bilateral visual loss four showed bilateral increased optic nerve signal and three unilateral increase. The involvement was of the mid and posterior intra-orbital sections over three 5 mm slices or more with sparing of the anterior portion. One patient with unilateral visual loss had increased signal only on the affected side. Brain MRI was normal, in marked contrast to the findings in clinically isolated optic neuritis in which multiple white matter lesions are seen in the majority.

Item Type: Journal Article
Publisher: BMJ Publishing Group
Copyright: © 1989 BMJ Publishing Group Ltd
Item Control Page Item Control Page