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Immunotherapies for Immune-Mediated myopathies: A current perspective

Needham, M. and Mastaglia, F.L. (2015) Immunotherapies for Immune-Mediated myopathies: A current perspective. Neurotherapeutics, 13 (1). pp. 132-146.

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Until recently, the treatment of immune-mediated inflammatory myopathies has largely been empirical with glucocorticoids, steroid-sparing immunosuppressive drugs, and intravenous immunoglobulin. However, a proportion of patients are only partially responsive to these therapies, and there has been a need to consider alternative treatment approaches. In particular, patients with inclusion body myositis are resistant to conventional immunotherapies or show only a transient response, and remain a major challenge. With increasing recognition of the different subtypes of immune-mediated inflammatory myopathies, and improved understanding of their pathogenesis, more targeted treatments are now being trialled. The overall approach to treatment, and novel therapies targeting B cells, T cells, and specific cytokines are discussed in this review.

Item Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Journal or Publication Title: Neurotherapeutics
Page Range: pp. 132-146
Publisher: Springer US
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