Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum
Tan, K.C., Trengove, R.D., Maker, G.L.ORCID: 0000-0003-1666-9377, Oliver, R.P. and Solomon, P.S.
(2009)
Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum.
Metabolomics, 5
(3).
pp. 330-335.
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Abstract
A recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916–1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.
Item Type: | Journal Article |
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Murdoch Affiliation: | School of Pharmacy |
Publisher: | Springer |
Copyright: | Springer |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/2799 |
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