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Locked nucleic acid as a novel class of therapeutic agents

Veedu, R.N. and Wengel, J. (2009) Locked nucleic acid as a novel class of therapeutic agents. RNA Biology, 6 (3). pp. 321-323.

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Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RNA targeting.

Item Type: Journal Article
Publisher: Taylor & Francis
Copyright: © 2009 Landes Bioscience
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