Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers
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Pasternak, K., Pasternak, A., Gupta, P., Veedu, R.N. and Wengel, J. (2011) Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers. Bioorganic & Medicinal Chemistry, 19 (24). pp. 7407-7415.
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Abstract
Efficient synthesis of a novel anthracene-functionalized 2′-amino-LNA phosphoramidite derivative is described together with its incorporation into oligodeoxynucleotides. Two DNA strands with the novel 2′-N-anthracenylmethyl-2′-amino-LNA monomers can be effectively cross-linked by photoligation at 366 nm in various types of DNA constructs. Successful application of three differently functionalized 2′-amino-LNA monomers in self-assembled higher ordered structures for simultaneous cross-linking and monitoring of assembly formation is furthermore demonstrated.
| Item Type: | Journal Article |
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| Publisher: | Elsevier Ltd. |
| Copyright: | © 2011 Elsevier Ltd. |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/27430 |
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