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Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides

Dubois, C., Campbell, M.A., Edwards, S.L., Wengel, J. and Veedu, R.N. (2012) Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides. Chemical Communications, 48 (44). p. 5503.

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Abstract

Enzymatic recognition of unlocked nucleic acid (UNA) nucleotides was successfully accomplished. Therminator DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of a 81 mer UNA-modified DNA library was efficiently achieved by KOD DNA polymerase.

Item Type: Journal Article
Publisher: Royal Society of Chemistry
Copyright: 2012 The Royal Society of Chemistry
URI: http://researchrepository.murdoch.edu.au/id/eprint/27409
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