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Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

Wheeler, M., Chardon, A., Goubet, A., Morihiro, K., Tsan, S.Y., Edwards, S.L., Kodama, T., Obika, S. and Veedu, R.N. (2012) Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases. Chemical Communications, 48 (89). pp. 11020-11022.

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Enzymatic recognition of SeLNA nucleotides was investigated. KOD XL DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of SeLNA-modified DNA templates was also efficiently achieved by Phusion and KOD XL DNA polymerases.

Item Type: Journal Article
Publisher: Royal Society of Chemistry
Copyright: 2012 The Royal Society of Chemistry
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