Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes
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Morihiro, K., Kodama, T., Kentefu, ., Moai, Y., Veedu, R.N. and Obika, S. (2013) Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes. Angewandte Chemie: International Edition, 52 (19). pp. 5074-5078.
Link to Published Version: http://dx.doi.org/10.1002/anie.201300555
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Abstract
Locking up selenium: A new conformationally restricted nucleic acid with a 2′,4′-selenomethylene bridge (SeLNA) can be reversibly converted into its oxidized form (SeOLNA), and the hybridization of a modified oligonucleotide was shown to be dependent on the oxidation state. A SeLNA-modified molecular-beacon-type probe (see scheme; F=fluorophore, Q=quencher) can be used as a sensor for changes in the redox environment.
| Item Type: | Journal Article |
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| Publisher: | Wiley |
| Copyright: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/27361 |
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