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Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo

Coles, D.J., Rolfe, B.E., Boase, N.R.B., Veedu, R.N. and Thurecht, K.J. (2013) Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo. Chemical Communications, 49 (37). pp. 3836-3838.

Link to Published Version: http://dx.doi.org/10.1039/c3cc00127j
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Abstract

Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.

Item Type: Journal Article
Publisher: Royal Society of Chemistry
URI: http://researchrepository.murdoch.edu.au/id/eprint/27293
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