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Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

Kim, K.T., Veedu, R.N., Seo, Y.J. and Kim, B.H. (2014) Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences. Chemical Communications, 50 (13). p. 1561.

Link to Published Version: http://dx.doi.org/10.1039/c3cc48853e
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Abstract

We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their PyU units.

Item Type: Journal Article
Publisher: Royal Society of Chemistry
Copyright: © 2014 Royal Society of Chemistry
URI: http://researchrepository.murdoch.edu.au/id/eprint/27285
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