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Metal-based antimalarial agents

Navarro, M. and Biot, C. (2014) Metal-based antimalarial agents. In: Storr, T., (ed.) Ligand Design in Medicinal Inorganic Chemistry. John Wiley & Sons Inc, Chichester, UK, pp. 205-225.

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The present chapter will describe the efforts made to discover novel metal-based antimalarial agents using ligand design to improve efficacy. Malaria is still one of the most devastating human parasitic infections; the search for new antimalarial drugs is a high priority, as the parasites that cause the disease have developed a high resistance to many of the drugs currently available for treatment. Consequently, the development of new chemotherapeutic agents more effective against malaria and less toxic to the host is urgent. Such efforts have to be accompanied by research on the biochemistry of the parasite, in order to identify possible targets of action for the rational design of better drugs, taking in account the importance of both the metal and the ligand to the overall potency.

Item Type: Book Chapter
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: John Wiley & Sons Inc
Copyright: © 2014 John Wiley & Sons, Ltd.
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