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Age at onset in two common neurodegenerative diseases is genetically controlled

Li, Y-J, Scott, W.K., Hedges, D.J., Zhang, F., Gaskell, P.C., Nance, M.A., Watts, R.L., Hubble, J.P., Koller, W.C., Pahwa, R., Stern, M.B., Hiner, B.C., Jankovic, J., Allen, F.H., Goetz, C.G., Mastaglia, F., Stajich, J.M., Gibson, R.A., Middleton, L.T., Saunders, A.M., Scott, B.L., Small, G.W., Nicodemus, K.K., Reed, A.D., Schmechel, D.E., Welsh-Bohmer, K.A., Conneally, P.M., Roses, A.D., Gilbert, J.R., Vance, J.M., Haines, J.L. and Pericak-Vance, M.A. (2002) Age at onset in two common neurodegenerative diseases is genetically controlled. The American Journal of Human Genetics, 70 (4). pp. 985-993.

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To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%–60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

Item Type: Journal Article
Publisher: Cell Press
Copyright: © 2002 The American Society of Human Genetics
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