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Investigating sodium valproate as a treatment for McArdle disease in sheep

Howell, J.Mc.C., Dunton, E., Creed, K.E., Quinlivan, R. and Sewry, C. (2015) Investigating sodium valproate as a treatment for McArdle disease in sheep. Neuromuscular Disorders, 25 (2). pp. 111-119.

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McArdle disease is due to an absence of the enzyme muscle glycogen phosphorylase and results in significant physical impairment in humans. We hypothesised that sodium valproate, an HDAC inhibitor, might have the ability to up-regulate the enzyme. We treated McArdle sheep with sodium valproate given enterically at 20-60 mg/kg body wt. Compared with untreated control animals, there was increased expression of phosphorylase in muscle fibres. The response was dose dependent and reached a maximum 2 hours after the application and increased with repeated applications. Improvement in mobility could not be demonstrated. These findings suggest that sodium valproate is a potential therapeutic treatment for McArdle disease.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: Elsevier BV
Copyright: © 2014 Elsevier B.V.
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