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Patterns of muscle Fiber-Type disproportion in hypotonic infants

Argov, Z., Gardner-Medwin, D., Johnson, M.A. and Mastaglia, F.L. (1984) Patterns of muscle Fiber-Type disproportion in hypotonic infants. Archives of Neurology, 41 (1). pp. 53-57.

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We studied the histochemical characteristics of muscle in five hypotonic infants. A number of different patterns of disproportion in the sizes and numbers of type 1 and type 2 fibers were found. In three cases, type 1 fibers were smaller than type 2 fibers and type 2b or 2c fibers were largest. In one case, type 2 fibers were smaller than type 1 fibers and were reduced in number, while in a case of Prader-Willi syndrome there was a pre-ponderance of type 2 fibers that were smaller than type 1 fibers. Type 2c fibers were increased in number in all but one case. We postulate that these various patterns of fiber-type disproportion are the result of altered neural influences leading to impaired maturation of type 1 or type 2 motor units.

Item Type: Journal Article
Publisher: American Medical Association
Copyright: © 1984 American Medical Association
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