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Galactocerebroside antiserum causes demyelination of cat optic nerve

Carroll, W.M., Jennings, A.R. and Mastaglia, F.L. (1985) Galactocerebroside antiserum causes demyelination of cat optic nerve. Brain Research, 330 (2). pp. 378-381.

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A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (< 5 μl) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect of myelin and on oligadendrocytes. The numbers of these cels within the lesion were initially reduced but subsequently increased as remyelination occured.

Item Type: Journal Article
Publisher: Elsevier BV
Copyright: © 1985 Published by Elsevier B.V.
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