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Untranslated gene regions and other Non-coding elements: Regulation of eukaryotic gene expression

Barrett, L.W., Fletcher, S. and Wilton, S.D. (2013) Untranslated gene regions and other Non-coding elements: Regulation of eukaryotic gene expression. Springer, Dordrecht, NL.

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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Item Type: Book
Murdoch Affiliation(s): Centre for Comparative Genomics
Publisher: Springer
Copyright: 2013 The Authors
Notes: Series Title: SpringerBriefs in Biochemistry and Molecular Biology; ISSN: 2211-9353
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