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The synthesis, characterisation and in vivo study of a bioceramic for potential tissue regeneration applications

Poinern, G.E.J., Brundavanam, R.K., Le, X.T., Nicholls, P.K.ORCID: 0000-0001-7071-3055, Cake, M.A.ORCID: 0000-0002-0072-9024 and Fawcett, D. (2014) The synthesis, characterisation and in vivo study of a bioceramic for potential tissue regeneration applications. Scientific Reports, 4 . Article number 6235.

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Hydroxyapatite (HAP) is a biocompatible ceramic that is currently used in a number of current biomedical applications. Recently, nanometre scale forms of HAP have attracted considerable interest due to their close similarity to the inorganic mineral component of the bone matrix found in humans. In this study ultrafine nanometre scale HAP powders were prepared via a wet precipitation method under the influence of ultrasonic irradiation. The resulting powders were compacted and sintered to form a series of ceramic pellets with a sponge-like structure with varying density and porosity. The crystalline structure, size and morphology of the powders and the porous ceramic pellets were investigated using advanced characterization techniques. The pellets demonstrated good biocompatibility, including mixed cell colonisation and matrix deposition, in vivo following surgical implantation into sheep M. latissimus dorsi.

Item Type: Journal Article
Murdoch Affiliation(s): School of Engineering and Information Technology
School of Veterinary and Life Sciences
Publisher: Nature Publishing Group
Copyright: © Poinern et al
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