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Secretory immunoglobulin A increases during relaxation in children with and without recurrent upper respiratory tract infections

Hewson-Bower, B. and Drummond, P.D.ORCID: 0000-0002-3711-8737 (1996) Secretory immunoglobulin A increases during relaxation in children with and without recurrent upper respiratory tract infections. Journal of Developmental and Behavioral Pediatrics, 17 (5). pp. 311-316.

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A diminished mucosal concentration of secretory immunoglobulin A (slgA) in the upper respiratory tract may increase susceptibility to colds and flu. The aim of the present study was to determine whether slgA increases during relaxation in children aged between 8 and 12 years with recurrent upper respiratory tract infections. Forty-five healthy children and 45 children with 10 or more upper respiratory tract infections in the previous year were randomly assigned to one of three experimental conditions: relaxation with suggestions to increase immune system proteins, relaxation alone, or a control condition. Samples of saliva were obtained before and after each condition. The concentration of slgA in the saliva samples was later determined by measuring the rate of precipitation of antigen-antibody complexes to a known concentration of slgA antigen. The concentration of slgA increased in the relaxation conditions but not in the control condition. The slgA/ albumin ratio (a more specific measure of local mucosal immunity than concentration) increased during the relaxation-suggestion condition but not during the relaxation or control conditions; however, both the concentration of slgA and the slgA/albumin ratio increased in proportion to subjective relaxation ratings. Neither response differed between healthy children and children with recurrent infections. The findings indicate that a disturbance in mucosal immunity in children with recurrent colds and flu does not limit increases in slgA during relaxation. Higher preinfection levels of slgA correlate with resistance to upper respiratory tract infection, so enhancing the slgA concentration with relaxation techniques may help children with recurrent infection problems

Item Type: Journal Article
Murdoch Affiliation(s): School of Psychology
Publisher: Lippincott Williams & Wilkins
Copyright: © Lippincott-Raven Publishers
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