Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Loss of facial sweating and flushing in Holmes-Adie syndrome

Drummond, P.D.ORCID: 0000-0002-3711-8737 and Edis, R.H. (1990) Loss of facial sweating and flushing in Holmes-Adie syndrome. Neurology, 40 (5). pp. 847-849.

Link to Published Version:
*Subscription may be required


We investigated pupillary responses to parasympathetic (pilocarpine) and sympathetic agents (tyramine, cocaine, and phenylephrine) in a 51-year-old woman with tonic pupils, loss of muscle stretch reflexes in the limbs, and hemifacial loss of sweating and flushing (Ross' syndrome). A smaller pupillary response to tyramine and cocaine eyedrops on the symptomatic side indicated that outflow was disrupted in the postganglionic section of the ocular sympathetic pathway. A greater response to phenylephrine eyedrops on this side was consistent with denervation supersensitivity to adrenergic agents. Loss of thermoregulatory sweating and flushing and emotional blushing in the forehead, cheek, and chin indicated that sympathetic disruption was proximal to the bifurcation of the common carotid artery, probably in the superior cervical ganglion. A similar degenerative process may be responsible for loss of muscle stretch reflexes, tonic pupils, and other autonomic disturbances in Ross' syndrome.

Item Type: Journal Article
Murdoch Affiliation(s): School of Psychology
Publisher: American Academy of Neurology
Copyright: © 1990 by the American Academy of Neurology
Item Control Page Item Control Page