Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Alzheimer's disease and apolipoprotein E genotype in Western Australia: An autopsy-verified series

Fabian, V.A., Jones, T.M., Wilton, S.D., Dench, J.E., Davis, M.R., Lim, L. and Kakulas, B.A. (1996) Alzheimer's disease and apolipoprotein E genotype in Western Australia: An autopsy-verified series. Medical Journal of Australia, 165 (2). pp. 77-80.

Abstract

OBJECTIVE: To determine the relationship between the apolipoprotein E epsilon 4 allele and autopsy-verified Alzheimer's disease (AD) in an Australian population.

DESIGN: Retrospective case-control study.

SETTING: Royal Perth Hospital, Perth, Western Australia (a tertiary referral hospital).

SUBJECTS: 50 subjects with "definite" AD (according to the histological and clinical criteria of the Consortium to Establish a Registry for Alzheimer's Disease [CERAD]) and 30 control subjects who had died from a non-neurological disease were randomly selected from the hospital's neuropathology register.

OUTCOME MEASURES: Histological grading of brain sections stained with the modified Bielschowsky stain according to the criteria of CERAD; number (burden) of neuritic plaques; apolipoprotein E genotype (APOE).

RESULTS: Frequency of the epsilon 4 allele was significantly higher in the AD group (37%) than in the control group (2%) (chi 2 = 25.8; P < 0.00001). In the AD group, 50% of subjects were heterozygous for the epsilon 4 allele and 12% were homozygous, while in the control group one subject was heterozygous for the allele and none were homozygous. No association was seen between the epsilon 4 allele and neuritic plaque burden in the hippocampus, entorhinal cortex, middle frontal gyrus or inferior parietal lobule in subjects with AD.

CONCLUSIONS: Our findings confirm an association between the epsilon 4 allele and autopsy-verified AD. The epsilon 4 allele may be an important risk factor for susceptibility to AD in the general Australian population.

Item Type: Journal Article
Publisher: Australasian Medical Publishing Company
Publisher's Website: https://www.mja.com.au/
URI: http://researchrepository.murdoch.edu.au/id/eprint/21788
Item Control Page Item Control Page