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Chagas disease: the challenge of polyparasitism?

Perez, C.J., Lymbery, A.J.ORCID: 0000-0002-0542-3446 and Thompson, R.C.A. (2014) Chagas disease: the challenge of polyparasitism? Trends in Parasitology, 30 (4). pp. 176-182.

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The debilitating zoonosis Chagas disease (CD) is caused by infection with the flagellate protozoan Trypanosoma cruzi. One century after its discovery, a curative agent remains elusive. Immune evasion by T. cruzi results in a poorly controlled infection in the host, which can end in either sudden death or a fatal chronic disease that often eventuates after years of an asymptomatic infection. Polyparasitism or mixed/concurrent infections occur more often than not and contribute to the high degree of variability observed across both disease progression and the success of therapeutic interventions. A thorough understanding of the effects of polyparasitism on CD is essential for improving the likelihood of containing, treating, and eventually eliminating CD.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: Elsevier BV
Copyright: © 2014 Elsevier Ltd.
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