Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Chagas disease: the challenge of polyparasitism?

Perez, C.J., Lymbery, A.J.ORCID: 0000-0002-0542-3446 and Thompson, R.C.A. (2014) Chagas disease: the challenge of polyparasitism? Trends in Parasitology, 30 (4). pp. 176-182.

[img]
Preview
PDF - Published Version
Download (316kB)
Link to Published Version: http://dx.doi.org/10.1016/j.pt.2014.01.008
*Subscription may be required

Abstract

The debilitating zoonosis Chagas disease (CD) is caused by infection with the flagellate protozoan Trypanosoma cruzi. One century after its discovery, a curative agent remains elusive. Immune evasion by T. cruzi results in a poorly controlled infection in the host, which can end in either sudden death or a fatal chronic disease that often eventuates after years of an asymptomatic infection. Polyparasitism or mixed/concurrent infections occur more often than not and contribute to the high degree of variability observed across both disease progression and the success of therapeutic interventions. A thorough understanding of the effects of polyparasitism on CD is essential for improving the likelihood of containing, treating, and eventually eliminating CD.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: Elsevier BV
Copyright: © 2014 Elsevier Ltd.
URI: http://researchrepository.murdoch.edu.au/id/eprint/21378
Item Control Page Item Control Page

Downloads

Downloads per month over past year