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Sweating in the intact horse and isolated perfused horse skin

Johnson, K.G. and Creed, K.E. (1982) Sweating in the intact horse and isolated perfused horse skin. Comparative biochemistry and physiology. C: Comparative pharmacology, 73 (2). pp. 259-64.

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1. In intact horses, heat-induced sweating occurred initially as pulses, then as a continuous, synchronously fluctuating discharge. 2. I.V. adrenaline (Adr) induced sweating immediately; isoprenaline (Isop) elicited sweating after a delay; and phenylephrine (PhE) had no sudorific effect. 3. In isolated perfused skin, PhE induced an immediate small sweat discharge, Isop a slower sustained output and Adr a biphasic discharge. alpha- and beta-adrenergic antagonists blocked the first and second phases, respectively, of Adr-induced sweating. 4. The observed sweating patterns are consistent with independent activation of alpha-adrenergic myoepithelium and beta-adrenergic secretory cells in the sweat glands. 5. Microcirculatory changes apparently also influenced sweat discharge.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Elsevier BV
Copyright: © 1982 Published by Elsevier Inc.
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