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Autoantibodies to pancreatic islet cells in canine diabetes mellitus

Haines, D.M. and Penhale, W.J. (1985) Autoantibodies to pancreatic islet cells in canine diabetes mellitus. Veterinary Immunology and Immunopathology, 8 (1-2). pp. 149-156.

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Indirect immunofluorescence on normal canine pancreatic tissue fixed in Bouin's solution was used to detect islet cell antibodies in dogs with diabetes mellitus, other endocrine diseases, and pancreatitis. 18 of 25 dogs with diabetes mellitus alone, 2 of 8 dogs with diabetes mellitus and concurrent pancreatitis, and 2 of 2 dogs with diabetes mellitus and concurrent pancreatic exocrine insufficiency were positive for autoantibody. 2 of 12 dogs with hypoadrenocorticism, 3 of 6 dogs with hyperadrenocorticism, 6 of 28 dogs with hypothyroidism and one of 19 dogs with pancreatitis alone were also antibody positive. None of 20 healthy dogs or 20 dogs with disorders other than those of the pancreas or endocrine organs were antibody positive.

Islet cell antibodies were demonstrated in dogs with diabetes mellitus and other endocrine disorders. The possibility of autoimmune involvement in the development of diabetes mellitus in the dog should be considered.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary Studies
Publisher: Elsevier BV
Copyright: © 1985 Published by Elsevier B.V.
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